Vaspin upregulation was found in obesity and T2D which was suggested to act as a compensatory mechanism and to exert anti-inflammatory action through binding to GRP78/MTJ-1, a cell-surface receptor complex, after being translocated to the plasma membrane in response to ER stress and protect against ER stress-induced metabolic disorders [77]. The gene discussed is DNAJC1; the disease is obesity due to melanocortin 4 receptor deficiency.