SNP analysis of chemerin rs17173608, apelin rs2235306, vaspin rs2236242, and omentin rs2274907 showed that the incidence of chemerin minor G allele (p = 0.001; OR = 2.6), vaspin major T allele (p = 0.001; OR = 2.01) and omentin minor T allele (p = 0.016; OR = 1.52) was significantly higher in RA patients than in control group. The gene discussed is SERPINA12; the disease is rheumatoid arthritis.