Finally, multivariate analysis was performed to assess the simultaneous effect of RA on serum levels of NF-κB, HIF-1α, MMP-3, VEGF, BAX, chemerin, apelin, vaspin, and omentin, as well as the serum gene expression levels of the investigated four adipokines (Table 4). The gene discussed is ITLN1; the disease is rheumatoid arthritis.