RARRES2 and rheumatoid arthritis: Also, chemerin was reported to induce expression of degradative mediators as MMP-3 in RA FLSs [58] and prevent apoptosis via activating chemR23/ calmodulin-dependent protein kinase kinase 2 (CAMKK2)/ adenosine monophosphate-activated protein kinase (AMPK) signaling pathway.