For NSCLC in particular, different studies have shown that TMB in the primary tumour tends to be higher in men than in women and is also positively correlated with tobacco consumption, KRAS, and BRAF mutated tumours, whereas the presence of ROS1 and ALK rearrangements is linked to lower TMB [36,37,38,39,40]. The gene discussed is ALK; the disease is neoplasm.