Because of this, blockage of the PD-1/PD-L1 axis may restart the anti-tumour activity of IFN-γ in responders, and observation of PD-L1 expressed in the tumour together with the presence of TILs was therefore proposed to determine whether a tumour is exhibiting immune evasion and could benefit from immunotherapy [53]. This evidence concerns the gene IFNG and neoplasm.