TP53 and toxicity: Specifically, in the study of Chang-Claude et al. [15], breast cancer patients carrying the rs1042522C allele were found to be at higher risk of telangiectasia compared to non-carriers, a finding that is in line with our results, while in the study of Tan et al. [33], no association was reported between TP53 rs1042522 and acute skin toxicity, although a trend towards decreased risk was found for carriers of the rs1042522C allele in normal-weight women.