While no data exist on the impact of rs1052555 on normal tissue radiosensitivity, the rs13181T allele (Lys 751) has been reported to lead to the sub-optimal repair of X-ray-induced DNA damage [37], but no impact of ERCC2 rs13181 has been reported in breast cancer patients in relation to the risk of radiation-induced acute skin reaction [38]. This evidence concerns the gene ERCC2 and breast cancer.