TP53 and toxicity: Conversely, TP53 rs1042522 was found to have an effect (OR per C allele: 1.52, 95%CI: 0.82–2.83, p = 0.186) in the same direction as that shown in the exploratory study and to be nominally associated with the risk of radiation-induced late skin toxicity in the overall combined cohort (OR per C allele: 1.79, 95%CI: 1.06–3.02, p = 0.028).