Besides TP53 rs1042522, two SNVs in ERCC2 (rs13181, rs1052555) and LIG1 rs7246696 reached a nominal level of statistical significance in our exploratory study, but these genetic variants were neither confirmed in the replication cohort nor found to be associated with the risk of radiation-induced late skin toxicity in the whole population of breast cancer patients. This evidence concerns the gene ERCC2 and breast cancer.