SREBF2 and metabolic syndrome: Recently, three single nucleotide polymorphisms (SNPs) of the SREBP2 gene in the intronic region, i.e., IVS11 + 414 G > A (rs1052717), IVS1 + 8408 T > C (rs2267439), and IVS12-1667 G > A (rs2267443), have been associated with T2DM [18] and metabolic syndrome [12].