The objective of this study was to examine the association of the SREBF2 gene (rs1052717, rs2267439, and rs2267443) and INSIG2 (rs7566605, rs11123469, and rs17587100) polymorphisms on the presence of obesity and dyslipidemia in Thai psychotic disorder patients treated with risperidone. Here, SREBF2 is linked to obesity due to melanocortin 4 receptor deficiency.