In this study, we investigated the association of the SREBF2 gene (rs1052717, rs2267439, and rs2267443) polymorphisms with obesity and dyslipidemia; a relationship between dyslipidemia and the SREBF2 gene rs2267443 (G/A) polymorphism was found. This evidence concerns the gene SREBF2 and obesity due to melanocortin 4 receptor deficiency.