To the best of our knowledge, this is the first study to examine the association of the SREBF2 gene (rs1052717, rs2267439, and rs2267443) and INSIG2 (rs7566605, rs11123469, and rs17587100) polymorphisms and the presence of obesity and dyslipidemia in Thai psychotic disorder patients treated with risperidone. This evidence concerns the gene SREBF2 and obesity due to melanocortin 4 receptor deficiency.