INSIG2 and obesity due to melanocortin 4 receptor deficiency: Since dyslipidemia often occurs alongside obesity, previous studies have found a relationship between the INSIG2 (rs7566605) polymorphism and lipid markers (total cholesterol, triglycerides low-density lipoproteins (LDL), and/or high-density lipoproteins (HDL)); however, there have been inconsistent findings [36,38].