Further studies are required to determine the impact of the SREBF2 and INSIG2 allelic forms on the response of obesity and dyslipidemia in the cells of rats exposed to risperidone for the elucidation of the functional consequence of the SREBF2 gene and INSIG2 polymorphisms. This evidence concerns the gene INSIG2 and obesity due to melanocortin 4 receptor deficiency.