Cholestatic biochemical profile with elevated gamma-glutamyl transpeptidase (GGTP) related with elevated transaminase levels were found in pediatric study concluded that abnormal liver enzymes with elevated GGTP levels (>252 U/L), were commonly found in pediatric IBD with associated primary sclerosing cholangitis (PSC) [32]. This evidence concerns the gene GGTLC1 and irritable bowel syndrome.