The expression of Rictor, phosphorylation of Rictor (Thr-1135), AKT (Ser-473) and PKCα (Ser-657) were all increased after IGF-1 and IL-6 treatment in both prostate cancer cell lines (Figure 5B,C) and in RWPE1 cells (Figure 5A). This evidence concerns the gene PRKCA and Familial prostate cancer.