Four genes were found to be involved in four cases each: the RAPSN gene related to fetal akinesia syndrome II [16,19], the SLC26A3 gene related to congenital chloride diarrhea [16], the L1CAM gene related to hydrocephalus with X-linked inherence [16,20], and the FOXC2 gene related to lymphedema-distichiasis syndrome [25]. The gene discussed is RAPSN; the disease is Lymphedema - distichiasis.