DOCK8 and hyperinsulinemic hypoglycemia, familial, 4: Clinically, patients with DOCK8 deficiency show a picture of combined immunodeficiency featured by recurrent cutaneous and respiratory infections, eczema, increased risk of malignancies, and predisposition to the development of atopy (with high IgE levels), and autoimmunity (cytopenia, thyroiditis, vasculitis, uveitis).