This has been achieved with combinations of (1) the use of dexamethasone (Dexa)-based 4 drug induction, (2) a more intensive Berlin-Frankfurt-Munster (BFM) ALL backbone, (3) Capizzi escalating methotrexate, and (4) optimizing the use of L-asparaginase (L-asp). The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.