Preventative studies with the acetylcholinesterase inhibitor donepezil hydrochloride, a commonly prescribed AD drug, were undertaken in younger individuals with DS; however, these studies were terminated prior to outcome measurements due to lack of efficacy [93,94,95], with the only completed study recently (20/04/2021) posting results showing little to no efficacy [96]. Here, ACHE is linked to Dravet syndrome.