The impact of OPN3 or OPN4 on tumor cell activities, such as drug sensitivity, growth, and metastasis, has been reported in hepatocellular carcinoma, colon cancer, and lung adenocarcinoma [113,114,115,116], and blue light (465 nm) exposure suppresses tumor growth by inducing autophagy [114]. This evidence concerns the gene OPN4 and malignant colon neoplasm.