Recently, the TRP melastatin (TRPM) family of ion channels, namely TRPM3, as well as TRPM2 to a lesser extent, and calcium (Ca2+) signalling dysregulation have been implicated in the pathophysiology of ME/CFS [5,6,7,8,9,10,11,12,13,14]. The gene discussed is TRPM2; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.