We also demonstrated that systemic proinflammation was associated with disease severity and that PMN %, ESR, CRP, TNF-α, IL-6, IL-8, MMP1, and MMP8 in peripheral blood increased with the severity of CPA in the univariate or multivariate analysis, consistent with previous investigations [22,23]. This evidence concerns the gene CXCL8 and congenital primary aphakia.