Even though several authors have found overexpression of MMP-2 and MMP-9 in cholesteatoma tissue and linked these findings to the aggressiveness of the cholesteatoma [5,6,8], we, on the other hand, did not find any statistically significant difference between the expression of MMP-2 and MMP-9 in cholesteatoma compared to the control tissue. The gene discussed is MMP2; the disease is cholesteatoma.