This transcription is responsible for the secretion of interleukins including: IL-1b, IL-6, and IL-8; Tumor Necrosis Factors: TNF-a, TNF-b; inducible cyclooxygenase (COX-2 favor prostaglandin synthesis); and inducible nitric oxide synthase (iNOS) [50,51,52]. Here, NOS2 is linked to neoplasm.