In particular, it was observed that a target of JNK signaling, the lipocalin Neural Lazarillo (NLaz)—the ortholog of human apolipoprotein D (ApoD)—is strongly expressed in HSD flies; in contrast, animals heterozygous for an NLaz null mutation are fully protected from HSD-induced insulin resistance [98]. The gene discussed is CHST3; the disease is Insulin resistance.