Endothelial-mesenchymal transition (EndMT) occurs during heart development [22] and Eltd1 and Gpr116 have been reported to function together to regulate this process, with loss of these two proteins in mice leading to malformation of the aortic arch as well the development of a thrombotic microangiopathy [23]. Here, ADGRF5 is linked to thrombotic microangiopathy.