The analysis of DNA methylation and expression changes in genes essential in gliomagenesis (Wnt pathway antagonists, SFRP1, RUNX3 and master cell cycle regulator, RASSF1A), and the impact on the expression of the crucial epigenetic regulator UHRF1 were evaluated to further decipher the molecular mechanisms exerted by CCM and NaBu in GBM cells. The gene discussed is RASSF1; the disease is glioblastoma.