The analysis of DNA methylation and expression changes in genes essential in gliomagenesis (Wnt pathway antagonists, SFRP1, RUNX3 and master cell cycle regulator, RASSF1A), and the impact on the expression of the crucial epigenetic regulator UHRF1 were evaluated to further decipher the molecular mechanisms exerted by CCM and NaBu in GBM cells. Here, UHRF1 is linked to glioblastoma.