The dysregulation of this set of PGR leads to many reproductive diseases, such as PCOS, POI, endometriosis, implantation failure, etc. Hence, identifying other novel PGR targets involved in the regulation of many P4 functions, most of which are yet to be identified, as well as their interactions, would be extremely beneficial for the diagnosis and treatment of female infertility. The gene discussed is PGR; the disease is polycystic ovary syndrome.