ERBB2 and neoplasm: Results presented in other studies in HER2-overexpressing cell lines revealed that other triterpenoids, naturally occurring (betulinic acid), but also synthetic OA’s derivative (2-cyano-3, 12-dioxooleana-1,9(11)-dien-28-oic acid, CDDO) suppress both tumor cell growth and colony formation and also activate apoptosis [10,11].