ERBB2 and breast cancer: Importantly, we already showed that two of them, methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate (HIMOXOL) and 12α-bromo-3-hydroxyimonoolean-28→13-olide (Br-HIMOLID) revealed cytotoxic activity against ER/PR-positive and HER2-negative (MCF7 and T-47D), and ER/PR/HER2-negative breast cancer cells (MDA-MB-468, MDA-MB-231) [8,9].