In unilateral ureter obstruction (UUO) mice, Drp1 was phosphorylated at serine 616 (p-Drp1S616) and pharmacological inhibition of mitochondrial fission reduced fibroblasts accumulation, and interstitial fibrosis along with decreased mitochondrial fragmentation and mitochondrial ROS, suggesting that inhibition of the phospho-Drp1S616-mediated mitochondrial fission attenuated fibroblast activation and proliferation in renal fibrosis [66]. Here, DNM1L is linked to renal fibrosis.