In cisplatin-induced AKI, treatment with AMPK activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) and the antioxidant agent acetyl-l-carnitine (ALCAR), which activates sirtuin3 (SIRT3) increased PGC-1α activity and improves renal function [56]. The gene discussed is PPARGC1A; the disease is acute kidney injury.