In UUO model, treatment with Mdivi-1 decreased mitochondrial PTEN-induced putative kinase 1 (PINK1), parkin RBR E3 ubiquitin protein ligase (PARK2), and LC3II levels; increased mtROS production; and worsened renal fibrosis following UUO [102], which suggested that Drp1-regulated PARK2-dependent mitophagy plays a protective role in kidney following injury. This evidence concerns the gene PRKN and renal fibrosis.