SMO and cancer: In silico analysis of publicly available datasets from the cBioPortal for Cancer Genomics (Skin Cutaneous Melanoma TCGA, PanCancer Atlas) [23,24] showed that the expression level of MAPK7 mRNA positively correlates with that of GLI1, GLI2, and SMO (Figure 3C), in keeping with the positive regulation of ERK5 by the HH-GLI pathway.