IL6 and chronic myelomonocytic leukemia: On one hand, these mice display increased intestinal permeability accompanied by the presence of Lactobacillus in the blood stream with consequent induction of systemic inflammation and IL-6 elevation; on the other hand, excessive myeloproliferation and extramedullary hematopoiesis resemble the clinical features of chronic myelomonocytic leukemia (CMML) [95,96].