There were only six canonical pathways that were identified both in the LV septal and LV free wall tissues, which were actin cytoskeleton signaling, RhoGDI signaling, signaling by Rho Family GTPases, integrin-linked kinase (ILK) signaling, liver X receptor/retinoid X receptor (LXR/RXR) activation, and cardiac hypertrophy signaling (Supplemental Table S5 and Supplemental Figure S2C,D). The gene discussed is ARHGDIA; the disease is cardiac hypertrophy.