SLC6A3 and Parkinson disease: Conversely, it is well known the dopaminergic contribution to cognition, mainly in frontal/executive performance, and empirical evidence for this hypothesis comes from several DAT imaging studies reporting a significant relationship between striatal dopaminergic denervation, especially in the caudate, and cognitive functioning [280,281,282,283], both in de novo [284] and advanced PD patients [285].