TP53 and Li-Fraumeni syndrome: Furthermore, the mutation of P53 has been reported to regulate the onsetof osteosarcoma [41] and in high grade osteosarcoma patients, almost 38% presented the mutation form of P53 while patients suffering from Li Fraumeni syndrome with a P53 congenital mutation have a risk of developing osteosarcoma that is restricted to 12% [6,42].