However, interleukin (IL)-4 and IL-13 secreted by T helper 2 (Th2) cells, eosinophils and basophils elicit an alternative polarization of TAMs to M2 macrophages, which in turn promote vascularization, tumor growth and invasiveness, cancer cell survival, and immunosuppression, all resulting in tumor progression [16]. The gene discussed is IL13; the disease is neoplasm.