To determine whether M1 or M2 macrophages play a role in tumor reduction in IL4RαKO-CAC mice, we evaluated colon M1-markers of classically activated macrophages through Toll like receptor 2 (TLR2) expression [23], as well as M2 markers through Programed Death Ligand 1 (PDL1) expression [24]. Here, CD274 is linked to neoplasm.