PRUNE2 and carcinoma: Yu et al. [41] identified a germinal mutation associated with somatic LOH at the gene locus on chromosome 9, two somatic missense mutations and two somatic nonsense mutations of the Prune Homolog 2 with BCH Domain (PRUNE2) gene, that all failed to be found in 40 sporadic PAs, revealing mutations of this gene as a recurrent event in carcinoma and as a possible distinctive genetic signature of sporadic PCs.