Differentially hypermethylated promoters in PCs, with respect to normal parathyroid tissue, were found in genes involved in apoptosis regulation, such as SOCS3 and PYCARD, or encoding transcription factors, such as HOXC11, GATA4 and HIC1, with a significantly higher hypermethylation of PYCARD, GATA4 and HIC1 promoters in PCs compared to benign PAs [52,53]. This evidence concerns the gene HIC1 and gonorrhea.