Moreover, a recent systematic review and meta-analysis on the performance of the sFlt-1/PlGF ratio in predicting adverse outcomes in women diagnosed or suspected of preeclampsia showed that the sFlt-1/PlGF ratio performs better in predicting women with early onset preeclampsia in comparison to those with late onset [65]; this relates to our previous topic in chapter 4 which described that defective uteroplacental vascular remodeling is mostly seen in the early onset type of preeclampsia. This evidence concerns the gene PGF and preeclampsia.