ALOX12 and type 2 diabetes mellitus: In a small study in 145 patients with T2DM and CKD, polymorphisms of the 12-lipoxygenase gene were associated with greater carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, and with a higher incidence of cardiovascular events and cardiovascular mortality during a 7-year follow-up period [43].