In a 2020 study [59], the authors investigated the MIR4435-2HG/miR-513a-5p/KLF6 axis, which upregulated in ccRCC KLF6, which is shown to be a typical suppressor of tumors of various localizations, including prostate tumors, colorectal tumors, etc. [85,86,87]. This evidence concerns the gene KLF6 and colorectal neoplasm.