Chondroitin sulfate synthase 1 (CHSY1), one of glycosyltransferases, exhibits oncogenic features, promoting the progression of hepatocellular and colorectal cancers and activating the hedgehog signaling pathway and the NF-kappa-B and/or the caspase-3/7 signaling pathways [79,80]. This evidence concerns the gene CHSY1 and colorectal cancer.