APP and Alzheimer disease: Lastly, using mice models of AD (APP/SEN1) where increased production of ROS has been demonstrated, Dixit et al. showed that while the deficiency of ascorbate, which is a well-known antioxidant, exacerbates mitochondrial oxidative stress as expected, the supplementation with this drug, not only mitigates the generation of ROS, but it also prevents mitochondrial membrane depolarization and, therefore, bioenergetics dysregulation [131].