Moreover, they showed that the mechanisms underlying this dissociation involve the accumulation of cyclin B1 in the areas of the brain affected in AD, due to the inactivation of the anaphase-promoting complex/cyclosome (APC/C)-cadherin 1 (Cdh1), which causes stabilization of cyclin B1, ultimately increasing cell death. The gene discussed is CCNB1; the disease is Alzheimer disease.