Although the renal protection of DPP-4 inhibition has been extensively investigated, mostly involving the glucagon-like-peptide-associated glycemic control, the anti-inflammasome effect in the renal fibrosis model [23], mitochondrial homeostasis [24], and anti-proteinuric effects [25] simply represent “pleiotropic” effects [26]. The gene discussed is GCG; the disease is renal fibrosis.