GZMB and type 2 diabetes mellitus: Due to limited access in brain GRs and because GRs are similarly regulated in the brain and immune cells [124,125], Panagiotou et al. assessed GC sensitivity as well as key GR signaling parameters (GRβ, pGR-S211, GILZ1, and FKBP5) in PBMCs of T2D patients [126].