HPSE2 and COVID-19: The importance of vWF in platelet activation is also prevalent in COVID-19, since its levels were found significantly increased in this scenario [130].The role of eGC has also been touched upon in the setting of COVID-19, with several studies highlighting glycocalyceal damage, an increase in biomarkers associated with eGC degradation, such as syndecan-1, hyaluronic acid, and sTie-2, as well as lower levels of eGC-protective markers such as heparanase-2 [131,132].