It was interesting to find within this GO group, the Small Proline Rich Protein 3 (SPRR3) recently proposed as a novel diagnostic and prognostic tumor marker of OSCC, since the survival analysis showed that its under-expression was associated to a poor prognosis, and that the decrease of SPRR3 expression corresponded to the increased the tumor malignancy [40]. This evidence concerns the gene SPRR3 and neoplasm.