Our results show a significant decrease in the number/tubule of the pre-meiotic cells SALL4 and PLZF (Figure 5A,B, respectively) (Supplement; Supplement Figure S1A,B; respectively) and in their expression levels (Figure 5A1,B1, respectively) in AML- and CYT-treated mice compared to CT mice. The gene discussed is ZBTB16; the disease is acute myeloid leukemia.