CASP3 and acute myeloid leukemia: However, 3-week post-injection of GCSF into AML- (AML + GCSF) and (AML + CYT)- (AML + CYT + GCSF), but not CYT- (CYT + GCSF), treated group significantly decreased the expression levels of BAX (intrinsic pathway) and FAS and CASP3 (extrinsic pathway) (to become similar to CT group) compared to AML-, (AML + CYT)- and CYT-treated groups (Figure 4C).