ZBTB16 and acute myeloid leukemia: However, with 3-week post-injection of GCSF in AML- (AML + GCSF), CYT- (CYT + GCSF) and (AML + CYT)- (AML + CYT + GCSF) treated mice, there was a significant increase in the number/tubule and expression levels of SALL4 and PLZF compared to AML-, CYT- (except for PLZF; did not change) and (AML + CYT)-treated mice (Figure 5A,A1,B,B1, respectively).