Increasing evidence has implied the correlation of Hsp90 and IPF by presenting the evidence of up-regulation of Hsp90 expression and activation of its ATPase function, facilitating matrix metalloproteinase activity, integrin expression, and epithelial-to-mesenchymal transition, all of which are involved in promoting the progress of fibrosis [39,40,41,42]. This evidence concerns the gene DNAH8 and idiopathic pulmonary fibrosis.