PLEKHS1 and obesity due to melanocortin 4 receptor deficiency: Kotoh et al. stated that the expression of PLEKHS1 is obesity-specific, with significantly different levels of PLEKHS1 mRNA expression being found between obese rats and obese rats with diabetes, but not between control and diabetic rats, suggesting PLEKHS1 to be a potential mediator of the onset of T2DM in obese rats [13].