Intriguingly, as reviewed in detail by Rybinska and colleagues, cancer-associated adipocytes share some common features with obese visceral abdominal adipocytes, such as the secretion of high levels of motility and extracellular matrix remodeling factors (e.g., CCL2, CCL5, autotaxin, MMPs), pro-inflammatory cytokines (e.g., IL-1β, IL-6, TNF-α, VEGF), and IR-associated adipokines (e.g., leptin, resistin) [153]. This evidence concerns the gene LEP and cancer.