NFKB1 and obesity due to melanocortin 4 receptor deficiency: At a molecular level, in obesity, the shift of the adipocyte secretome to a pro-inflammatory profile is triggered by the hypoxic status of the adipose tissue of the obese via the hypoxia-inducible factor-1 (HIF-1) [143,144], a nuclear protein which, by interacting with HMGA1 and the transcription factor NF-kB, a master regulator of inflammation, may modulate the transcription of several relevant genes [145,146,147].