FBXW7 and obesity due to melanocortin 4 receptor deficiency: The miRNA miR-223 has been implicated in IR and obesity by modulating STAT signaling pathways, the toll-like receptor 4 (TLR4), and the F-box/WD repeat-containing protein 7 (FBXW7), a negative regulator of adipogenesis and a tumor suppressor in many cancer types [235].