PROM1 and glioblastoma: First, we analyzed whether inhibition of PIM1 kinase results in an altered expression of candidate stem cell markers (CD44, CD133, Nestin), as well as of the microglia (SPARC) and astrocytic marker protein (GFAP) in the human adherent GBM cell lines LN-18 and U-87 MG on the mRNA level.