SV2A and hepatocellular carcinoma: BoNT HCC/A binds neurons and is internalized by activity-dependent pathways where BoNT/A HCC binds to a polysialoganglioside, such as GT1b, enriched on the presynaptic extracellular membrane surface, followed by association with synaptic vesicle protein 2 (SV2) [12,13,14].