Given that the AD pathologic increase of phospho-Tau and Aβ in the entorhinal cortex, which induce synaptic weakening in the hippocampus [35,37], laminar differences in the GIRK2 expression suggest a potential circuit specificity in the alteration, and related with entorhinal cortical pathology. The gene discussed is KCNJ6; the disease is Alzheimer disease.