Recently, it was reported that overexpression of histone demethylase Phf2, which belongs to the KDM7 histone demethylase family, favored hepatic steatosis development, but protected the liver from inflammation and oxidative stress by desaturation of detrimental saturated fatty acid into DAG and TG, and fibrosis development [4]. The gene discussed is PHF2; the disease is Hepatic steatosis.