Recent studies using various models of neuropathic pain strongly suggest that spinally located neuronal CXCR2 and CXCR3 are predominantly responsible for disturbed nociceptive transmission [21,22,24,28,51], although these receptors are also present on activated microglia and astrocytes; thus, these cells are known to be important for neuropathy development [21,22,34,44,52]. Here, CXCR2 is linked to neuropathy.