In two patients (patients 11 and 16) who developed ALF and underwent LT, the dramatic scores for the standard biological parameters (INR, bilirubin, and creatinine) were indicative of severe liver failure and associated with low concentrations of ADH1B from the time of hospital admission (patient 11), or after the cytolytic episode (patient 16) (Figure 4). The gene discussed is ADH1B; the disease is Hepatic failure.