PTGS2 and neoplasm: In collaboration with early growth response 1(EGR1) and SP1, SNAI1 may directly activate transcription of p15INK4b, lymphoid enhancer-binding factor (LEF), and cyclooxygenase 2 (COX2) by directly binding on a consensus motif in HepG2 cells stimulated by the phorbol ester tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) [5,8,9,10].