While nesfatin-1 peptide umbilical cord blood levels were decreased in LGA newborns compared to AGA infants [261], circulating NUCB2/nesfatin-1 in SGA and IUGR babies was increased compared to normal weight neonates [262,263], even 7 and 28 days after birth [262]. The gene discussed is NUCB2; the disease is fetal growth restriction.