CD274 and metastatic malignant neoplasm: Various clinical studies are ongoing using a PEGylated IL-2 agonist binding CD122 (bempegaldesleukin, NKTR-214) combined with anti-PD-L1 or anti-PD-1 in solid metastatic cancers (NCT03138889), one of which is testing a combined treatment with intratumoral injection of a TLR agonist (NKTR-262) (NCT03435640).